Abstract
1. 1. Isolated perfused livers from mice infected with Trypanosoma brucei rhodesiense formed substantially more [3- 13C]-lactate from [3- 13C]-alanine than livers from uninfected mice. Quantities formed by infected livers increased as infection progressed. 2. 2. Infected livers produced more 13C-labeled glutamate and glutamine, with label scrambled between C-2 and C-3. Scrambling also produced [2,3- 13C]-aspartate, [2- 13C]-alanine and [2- 13C]-lactate. Delayed appearance of label in C-4 of glutamate/glutamine in infected liver reflects significant endogenous stores of unlabeled acetyl CoA. 3. 3. Although differences do exist in catabolism of [3- 13C]-alanine by perfused livers from infected and control mice, trypanosomiasis does not cause permanent breakdown or blockage of hepatic alanine metabolism.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Comparative Biochemistry and Physiology -- Part B: Biochemistry and Molecular Biology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
