Abstract
BACKGROUND CONTEXT: Spine degeneration affects a substantial proportion of the population. Numerous studies have given insights into structure-function-failure relationships mostly attributable to decreased disc-cell density and reduction of synthesis of disc-specific extracellular matrix proteins such as collagens and proteoglycans by disc chondrocytes. Given the value of disc chondrocytes to the metabolic health of the disc, as a novel therapeutic strategy for disc tissue restoration the autologous disc chondrocyte transplantation (ADCT) was developed: patient-specific disc chondrocytes were isolated, propagated according to the drug law and transplanted into the degenerated disc (1). In a canine model (2) as well as in human pilot trials (1) the functional and structural stabilization of degenerated discs was shown clinically.
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