1278-P: Prevalence of Untreated Prediabetes and Alterations of Glucose Metabolism in Mexico—A Nationally Representative Analysis Spanning 2016–2021

Abstract

Background: Identifying phenotypes at risk of diabetes may be useful in guiding prevention efforts. Here, we estimated the prevalence of glucose metabolism disturbances in Mexico and the association of different prediabetes criteria with cardiometabolic conditions. Methods: We conducted a serial cross-sectional analysis of National Health and Nutrition Surveys in Mexico (2016-2021), excluding individuals with diagnosed or undiagnosed diabetes. Prediabetes was defined using ADA (FPG 100-125 mg/dL and/or HbA1c 5.7-6.4%), WHO (FPG 110-125 mg/dL), and IEC criteria (HbA1c 6.0-6.4%). Results: We analyzed a total of 21,440 participants. Prediabetes prevalence in Mexico rose between 2020 (19.2% [95% CI: 17.1-21.4]) and 2021 (27.3% [24.4-30.2]) (Fig1A), with the increase largely driven by higher HbA1c (Fig1B). Prediabetes prevalence was highest in older adults (≥60 years), individuals with obesity (BMI ≥30 kg/m2), and those with high social disadvantage. Prevalence of prediabetes defined by concordant ADA, WHO and IEC criteria were low; however, these definitions better identified cardiometabolic alterations (Fig1C). Conclusion: The burden of prediabetes is rising in Mexico and in high-risk populations. Use of concordant ADA criteria and higher diagnostic thresholds may help identify subjects at increased risk of cardiometabolic comorbidities. Disclosure C.Fermín-martínez: None. C.D.Paz cabrera: None. J.Perezalonso espinosa: None. N.Antonio villa: None. D.Ramírez-garcía: None. A.Vargas-vázquez: None. L.Fernández chirino: None. J.A.Seiglie: Consultant; BDMT Global, Techspert Expert Network. O.Bello-chavolla: None.