Abstract
Background: Regional lymph node involvement is the most important prognostic factor in cutaneous melanoma. Since only 20% of melanoma patients have occult nodal disease and would benefit from a regional lymphadenectomy, the sentinel lymph node (SLN) biopsy was introduced. NIR fluorescence has been hypothesized to improve SLN mapping. The objective was to assess the potential of intraoperative near-infrared (NIR) fluorescence imaging to improve SLN mapping in melanoma patients and to establish the optimal dose of indocyanine green adsorbed to human serum albumin (ICG:HSA).
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