120-POS

Abstract

Objectives Preeclampsia is a complex multi-systemic disorder of human pregnancy characterized by hypertension and proteinuria, and frequently associated with altered renal function. Serum level of cystatin C seems to reflect the glomerular filtration rate and is associated with preeclampsia. Considering that the serum level of cystatin C is a good marker for glomerular filtration the present study aimed to compare the levels of cystatin C, urea and creatinine in serum and proteinuria in preeclamptic pregnant women. Methods Sixty-seven women with preeclampsia and 20 normotensive pregnant women matched for gestational age were included. Preeclamptic women were classified according to the proteinuric levels in 24 h-urine as: mild proteinuria (0.3–1.99 g/24 h; n = 27); severe proteinuria (2.0–9.99 g/24 h; n = 28) or massive proteinuria (⩾10.0 g/24 h; n = 12). Serum levels of urea and creatinine were determined using commercially available assay kits, and cystatin C levels were evaluated using an enzyme-linked immunosorbent assay. Comparisons between pregnant groups were analyzed by non-parametric tests with significance set at p Results Cystatin C level in preeclamptic women with massive proteinuria was significantly higher than in severe and mild proteinuria groups as well as in the normotensive one. Moreover, patients with severe proteinuria had higher levels of cystatin C compared with mild proteinuria. The levels of urea and creatinine were higher in massive proteinuria compared with mild proteinuria. Correlation analysis between cystatin C and the other parameters showed association with proteinuria (r = 0.3262; p = 0.0043), urea (r = 0.3493; p = 0.0023) and creatinine (r = 0.3319; p = 0.0037). Conclusions Association between serum level of cystatin C with the markers of renal function such as urea and creatinine, as well as with different degrees of proteinuria, suggest that cystatin C may be employed as a marker of renal injury and preeclampsia severity. Disclosures R.A. Costa: None. M.T. Peracoli: None. M. Romao: None. I.C. Weel: None. J.F. Abbade: None. J.C. Peracoli: None.