Abstract
loads (median delta of HCVRNA viral load 2.8 log10 IU/ml) versus CT/TT genotypes (1.4 log10 IU/ml) before initiation of therapy. The maximum viral load drop within 100 days after diagnosis was higher in patients with fluctuating viremia (FV) (median 2.9 log10 IU/ml) and in patients with SC (median 3.1 log10 IU/ml) in comparison to individuals with plateau viremia (median 0.5 log10 IU/ml). Patients with FV and SC together had higher median peak bilirubin (1.8 versus 0.8mg/dl) and ALT levels (1146 versus 265 U/l) in comparison to patients with plateau viremia. No mutational patterns within the NS3 protease were detected in correlation with the outcome of acute HCV infection. Conclusions: A maximal viral load drop ≥ 2.9 log10 IU/ml is associated with higher peak bilirubin and ALT levels and occurs in SC patients and in patients with FV and persistent outcome of acute HCV infection. Highly fluctuating HCVRNA concentrations were observed in patients with IL28B CC genotype in comparison to CT/TT genotypes.
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