1010 AMERICAN SOCIETY OF ANESTHESIOLOGISTS (ASA) PHYSICAL STATUS CLASSIFICATION AND CHARLSON SCORE ARE INDEPENDENT PREDICTORS OF SURVIVAL AFTER RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyProstate Cancer: Localized (IV)1 Apr 20131010 AMERICAN SOCIETY OF ANESTHESIOLOGISTS (ASA) PHYSICAL STATUS CLASSIFICATION AND CHARLSON SCORE ARE INDEPENDENT PREDICTORS OF SURVIVAL AFTER RADICAL PROSTATECTOMY Michael Froehner, Anna-Elisa Kellner, Rainer Koch, and Manfred Wirth Michael FroehnerMichael Froehner Dresden, Germany More articles by this author , Anna-Elisa KellnerAnna-Elisa Kellner Dresden, Germany More articles by this author , Rainer KochRainer Koch Dresden, Germany More articles by this author , and Manfred WirthManfred Wirth Dresden, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.594AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To investigate the interaction of comorbidity classifications as prognostic parameters in patients selected for radical prostatectomy. METHODS A sample of 2205 consecutive patients with a mean age of 64 years and a mean follow-up of 9 years was studied. The following prognostic variables were studied: age (continous variable); PSA 10+ ng/mL or neoadjuvant treatment vs. lower; Gleason score (8+ vs. lower); pT stage (3-4 vs. 2); lymph node status (positive vs. negative); ASA class (3 vs. 1-2); Charlson score (2+ vs. 0-1), New York Heart Association class of cardiac insufficiency (2+ vs. lower); Canadian Cardiovascular Society class of angina pectoris (2+ vs. lower); number of concomitant diseases (2+ vs. lower); diabetes with end organ damage (present vs. absent), body mass index (35+ vs. lower). Patients with missing data in one of these categories were excluded thus leaving 2133 patients for analysis. Cox proportional hazard models were calculated with overall survival as endpoint. RESULTS The following variables were independent predictors of overall survival: age (hazard ratio (HR) per year 1.06, 95 % confidence interval (CI) 1.04-1.08, p<0.0001, Gleason score (HR 2.22, 95 % CI 1.72-2.87, p<0.0001), lymph node status (HR 1.71, 95 % CI 1.25-2.34, p=0.0009), ASA class (HR 1.66, 95 % CI 1.23-2.23, p=0.0008), Charlson score (HR 1.76, 95 % CI 1.31-2.37, p=0.0002). CONCLUSIONS Both the Charlson score and the ASA class contribute independent prognostic information on the survival probability after radical prostatectomy. This finding indicates that these comorbidity classifications may measure different aspects of a patient's health status. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e415 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michael Froehner Dresden, Germany More articles by this author Anna-Elisa Kellner Dresden, Germany More articles by this author Rainer Koch Dresden, Germany More articles by this author Manfred Wirth Dresden, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...