Abstract

Abstract An improved strategy for synthesis of 1-chloro-bicyclo[2.2.2]octane is described in which the key compounds 1-norborny substituted ethyl formate(3) or 1-norbornylcarbaldehyde (7) were prepared from 1-norbornyllithium(1). The latter appeared as a useful precursor for the synthesis of various organic bridgehead substituted derivatives.

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