実験的高血圧症の研究(第1報) : Lysolecithin及びLysocephalin

Abstract

Lysolecithins were made from the kidneys (of rabbits or oxen) and eggyolk, and lysocephalins were done from the kidneys (of rabbits or oxen) and erythrocytes. Mainly, the effects of these products on blood pressure were observed. In the course of experiment, clinical examinations were made of urine, peripheral blood picture, body weight, body temperature, blood sugar and nonprotein nitrogen level in blood. After the animals were killed, histological examinations were also performed.The results obtained were as follows : 1) In short-term experiments, lysolecithin depressed the blood pressure in rabbits, irrespective of whether it was made from kidneys of rabbits or from eggyolk. Marked hemoglobinuria and hematuria occurred during the course of the experiment.2) In long-term experiments, the blood pressure was not changed in rabbits or rats by any amount of lysolecithin. Hemoglobinuria, slight albuminuria and glycosuria were observed during the course of the experiments.3) With lysocephalin, made from kidneys the blood pressure of rabbit was not so much changed in short-term experiment, namely, the blood pressure level was lowered immediately following the injection, but was restored quickly and it even tended to rise above the normal level.4) In the long-term experiment with lysocephalin made from kidney or erythrocytes the blood pressure of rabbits tended to rise immediately, but was restored to normal level again. In this aspect, the blood pressure was not elevated by salt-loading. In the long-term experiment with lysocephalin made from kidney the blood pressure of rats tended to rise on the 7th to 14th day after the injection of lysocephalin and maintained the slight elevation of blood pressure during one or two months, but thereafter it returned to the normal level. In this aspect, no further use was produced by the addition of egg albumin or acetoacetic acid injection. The change in urine was observed in all of the animals, namely, hematuria, slight glycosuria and albuminuria occurred. But the marked change was not observed in peripheral blood picture, body temperature, body weight, blood sugar and nonprotein nitrogen level in blood.3) The histologic changes in the kidney were very slight and almost the same in all cases. Heart and other organs remained intact.6) The blood pressure level measured by KAWAGUCHI's indirect method, was very labile and was not reliable.From these results it is concluded that lysolecithin showed no pressor effect in either short-term or long-term experiments, and only lysocephalin made from kidneys showed a slight pressor effect when used over a long period of time.