Abstract
The ligands of the title complexes1 and2 were prepared from the pertinent chalcone5 and hydrazine hydrate, followed by N-N cleavage. The estrogenic activity of the diamines11 and12 was determined by measuring the RBA values (calf uterine cytosol) and by a luciferase test in MCF 7-2a cells. The compounds are by far less active thanSchonenberger's most active compound ([meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethane-1,2-diamine]dichloro-platinum(II),3).
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