Abstract
A convenient and novel 1,3-dimethylbarbituric acid-mediated methodology for constructing diverse benzimidazole-fused heteroaromatics has been developed. This metal-free cascade annulation of readily available 3-formylchromones, 1,2-diaminoarenes, and cyclic 1,3-dicarbonyl compounds provides an alternative synthetic route in the green conditions. 1,3-Dimethylbarbituric acid acts as a protecting group and accelerates intramolecular cyclization. This one-pot protocol proceeds through cascade nucleophilic addition, ring-opening, Michael-type addition, intramolecular cyclization, elimination, and air oxidation reactions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
