Abstract
AbstractEight water‐soluble 1,1′‐dimethylvanadocene amino acid complexes have been prepared via the reaction of (MeCp)2VCl2 (2) with one equivalent of amino acid (aa) in water affording [(MeCp)2V(aa)]Cl, where aa is glycine (3), L‐alanine (4), L‐valine (5), L‐leucine (6), L‐isoleucine (7), L‐phenylalanine (8), L‐histidine (9) and L‐tryptophane (10). All prepared complexes have been characterized by EPR, IR and Raman spectroscopy, elemental analysis and mass spectrometry. Molecular structures of [(MeCp)2V(ala)]BPh4·CH3OH (11), [(MeCp)2V(leu)]PF6 (12) and [(MeCp)2V(ile)]PF6 (13) were determined by X‐ray diffraction analysis. Cytotoxic properties of complexes 2–10 were investigated toward Escherichia coli B and compared with analogical unsubstituted vanadocene compounds (1, 14–21). The results showed that 1,1′‐dimethylvanadocene amino acid complexes have identical or slightly higher antiproliferative activity then their unsubstituted analogs. Copyright © 2006 John Wiley & Sons, Ltd.
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