Abstract
We hypothesize that skin cancer emerges from a combination of mutations and tissue disruption. We characterize clonal dynamics and transcriptional signatures during skin carcinogenesis using lineage tracing. For 3 months, we UV-irradiated fluorophore expressing K14Cre-ERT2 Confetti mice. Clone volumes were computed from 3-D digitized confocal z-stacks. scRNAseq was used to compare UV-exposed (EXP) epidermis, non-exposed (NON), and tumors. Over 6 months from the UV initiation, we generated 914 serial images of the EXP/NON skin.
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