Abstract
Psoriasis is a multifactorial disease associated with both genetic and non-genetic factors. We hypothesized that single nucleotide polymorphisms (SNPs) in aldo-keto reductase (AKR) 1C3, which regulates keratinocyte differentiation and loricrin expression in human epidermis, confer a genetic susceptibility to psoriasis. In 232 psoriasis patients, including 171 males and 61 females, a TaqMan SNP genotyping assay revealed that the rs12529 genotype distribution in our cohort was G/G: 75.0%, G/C: 22.8%, and C/C: 2.2%, and the rs12387 genotype distribution was A/A: 75.0%, A/G: 22.8%, and G/G: 2.2%.
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