Abstract
Type 1 interferons (IFN-1) are major drivers of disease activity in systemic (SLE) and cutaneous lupus erythematosus (CLE). Plasmacytoid dendritic cells (pDCs) are the major producers of IFN-1 during viral infection. pDCs are reduced in the circulation in SLE and have recently been shown to have an exhausted phenotype, suggesting that pathogenic pDCs were located in the end organs. We performed imaging mass cytometry of treatment naïve CLE skin (n=48), which revealed only 8.5% (IQR 0.0-22.22) of pDCs were IFNa+.
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