Abstract
Hidradenitis suppurativa (HS) is a chronic inflammatory dermatosis characterised by painful nodules, abscesses and sinus tracts, typically in flexural sites. It has an estimated prevalence of 2% and can be severely debilitating. The inflammatory and immune landscape underlying HS remains poorly understood and treatment options are limited or only partially effective. We have performed global transcriptional profiling at single-cell and spatial resolution on axillary HS skin. This has revealed striking differences in comparison to healthy skin and other inflammatory skin diseases such as psoriasis and eczema.
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