Abstract
Late inspiratory rise in airway pressure (LIRAP, ΔPaw/Δt, Fig. Fig.1)1) caused by inspiratory muscle relaxation or expiratory muscle contraction is frequently seen during pressure support ventilation [1, 2], although the factors that modulate LIRAP are unknown. Figure 1 Objectives The aim of current study was to determine the factors related to LIRAP during PSV using a simulation lung model. Influence of inspiratory muscle relaxation was assessed under various combinations of lung models and ventilator settings. Influence of expiratory muscle contraction was assessed through its intervention at various time points during the inspiratory phase.
Highlights
Late inspiratory rise in airway pressure (LIRAP, ΔPaw/ Δt, Fig. 1) caused by inspiratory muscle relaxation or expiratory muscle contraction is frequently seen during pressure support ventilation [1,2], the factors that modulate LIRAP are unknown
We investigated the effects of respiratory mechanics, inspiratory effort (-2, -8, or -15 cmH2O), flow cycling-off criteria (5-40% peak inspiratory flow), and duration of inspiratory muscle relaxation (0.18-0.3 s) on LIRAP during pressure support ventilation using a lung simulator (ASL 5000) and four types of ventilators
LIRAP occurred within all lung models when inspiratory effort was medium to high and duration of inspiratory muscle relaxation was short
Summary
The aim of current study was to determine the factors related to LIRAP during PSV using a simulation lung model. Influence of inspiratory muscle relaxation was assessed under various combinations of lung models and ventilator settings. Influence of expiratory muscle contraction was assessed through its intervention at various time points during the inspiratory phase
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