Abstract
Peyronie′s disease (PD) is inherited in autosomal dominant fashion in a subset of men. Recent work examining genetic risk factors identified genes involved in human carcinogenesis. Here, we examine the risk of cancer among a large sample of men with PD. We analyzed subjects contained within the Truven Health MarketScan claims database from 2007-2014. This U.S. database provides information of insurance claims filed for the care of privately-insured individuals with employment-based insurance. Men with PD or erectile dysfunction (ED) were identified through diagnosis (ICD-9) codes. An age and follow-up time matched control cohort of men was also created. men with any claim with a diagnosis code for cancer before the index date or within 1 year after the index date were excluded (ICD9 140–209, excluding skin squamous cell, basal cell, and non-invasive cancers). The incidence of cancer was compared among each group utilizing a Cox regression model.
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