Abstract
γδ T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programed rearrangement of Vy-gene segments. It appears that the T-cell receptor repertoire, at least of the γδ T cells with invariant receptors, is the result of site-directed rearrangement and cellular selection does not play a major role.
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