Abstract
The radiation decomposition yields of aminobenzylpenicillin in the anhydrous and hydrated forms were determined. The effect of water of crystallization on the decomposition yield of the thiazolidine-beta-lactam system and on the deamination of aminobenzylpenicillin was studied. On the basis of spectropolarimetric and iodometric measurements and by comparing the I.R. and N.M.R. spectra of irradiated and non-irradiated samples, the most radiosensitive fragments of the penicillin molecule were detected, and the relation between total changes in aminobenzylpenicillin and those pertaining to the thiazolidine-beta-lactam system was determined. On the basis of radiation-induced changes in the N.M.R. and I.R. spectra of aminobenzylpenicillin and from spectroscopic studies on the radiolysis products isolated, a radiolysis pattern of solid aminobenzylpenicillin is suggested.
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