Abstract
In this study, we investigated the anti-inflammation effect of Potentilla chinensis (PC) on Raw264.7 macrophage cells. Ethanol extract of PC decreased the production of nitric oxide (NO) in LPS-stimulated RAW264.7 cells. Ethanol extract was fractioned by n-hexane, chloroform, ethyl acetate, n-butanol, water and each fraction was tested for inhibitory effects on inflammation. Among the sequential solvent fractions, PC chloroform extracts (50, 100, 300, and 500 <TEX>${\mu}g/mL$</TEX>) significantly suppressed LPS-stimulated production of NO. During the entire experimental period, 200 and 300 <TEX>${\mu}g/mL$</TEX> of PC chloroform extracts had no cytotoxicity. LPS-induced NO and prostaglandin <TEX>$E_2$</TEX> (<TEX>$PGE_2$</TEX>) production were inhibited by PC chloroform extracts up to 50% and 90% of these productions, respectively. PC chloroform extracts reduced the expression of iNOS and COX-2 gene. These results suggest that PC chloroform extracts exhibit strong effects of anti-inflammation and can be a potential candidate in the treatment of acute and chronic inflammatory diseases.
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