Abstract
Study on insulin-like growth factor-1 (IGF-1) which plays a role in regulating proliferation, differentiation, growth, and survival in vertebrates, has been reported mainly in fish and a correlation between IGF-1 activity and growth has been described in some bivalves. In Korea, the Pacific oyster Crassostrea gigas is an important species, and its growth and reproduction were dependent on the condition index (CI) and tissue weight rate (TWR). Therefore, we investigated effects of the expression of IGF-1 signal in mantle edge, gill, labial palp and digestive gland of C. gigas during about 1 year, using immunoblot analysis to assess the relationship between IGF-1 receptor (IGF-1R) activity and CI. The activation of the IGF-1 signaling pathway, including the IGF-1R ß-subunit, could be detected high in May when CI and TWR were high. IGF-1R was activated and regulated the downstream IGF-1 signaling in tissues of C. gigas. However, the level of each factors of IGF family expression was depended on tissues and month. These results suggest that the increased activation of IGF-1 signal could be related to the condition index of C. gigas.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
