Abstract

The purpose of this study was investigate the effect of aerobic exercise on high sensitivity C-reactive protein(hs=CRP), inflammatory markers, and cardiovascular risk factors in obese women. Nineteen obese women(body mass indexs≥25) aged 40 to 53 years were randomly assigned to either a training or control group. The training program consisted of 12 weeks of supervised aerobic exercise(60%VO2R, 60min) three times a week on treadmill. Body weight, BMI, percent of body fat, and waist circumference were significantly decreased after training. Aerobic exercise significantly decreased cardiovascular risk factors and inflammatory markers, including fibrinogen, leptin and IL-6 whereas CRP and adiponectin did not change. The reduction of weight after training was positively associated with the decrease of SBP, TC, TC/HDL-C, TG, CRP, leptin, and IL-6. The change of CRP was positively associated with that of fibrinogen and leptin(p.05), and also a positive correlation between the changes of leptin and IL-6 was observed(p.01). As a results, a 12-week aerobic exercise intervention improved cardiovascular risk factors as well as inflammatory markers including fibrinogen, IL-6 and leptin, but had no effect on the modification of CRP despite the improvement of body composition in obese women.

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