Abstract
Twelve kinds of 2-pyrazolin-5-one derivatives, substituted in the 1, 3, or 4 position were synthesized and relationship between their structure and antitubercular action was examined. With the exception of 3-methyl derivatives, compounds substituted in the 1, 3, or 4 position were found to have generally weaker antibacterial action. The action of the 3-methyl derivative against human-type tubercle bacilli, H37RV strain, was equal to that of 2-pyrazolin-5-one and was effective up to a concentration of 3 γ/cc.
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