Abstract
The attempts were made to isolate the agents into the tissue culture human embryonal skin muscle cells, from the fecal specimen of a case with typical Guillain-Barré syndrome, namely the dissociation of “cyto-albumique” of spinal fluid, paralysis of both legs and without fever, of age 5 years old boy. The cytopathogenicity was observed clearly at 5th tissue culture passage level following three days of incubation. The pattern of this changes were of similar nature to that of polio's. The maximum TCID50 was revealed to be of the vicinity of 10-4.5/ml. Neutralizing antibody was found in the patients sera against this agent, which was not apparently neutralized with 3 types of polio-antisera and their mixture sera. The agent was temporary designated as “Kakiki Strain”, of which neutralizing antibody titre exhibited 1:64 in both paired sera obtained at 12th and 21st day of illness. No discernible changes were observed in the tissue culture HeLa cells and chick embryo fibroblast cells No pathogenic effect was shown in suckling and adult mice as well as in the developing chick embryo inoculated through the chorioallantoic route and yolk sack route. The suggestion would seem to be made in the line that this agent could be of similar character to ECHO viruses.
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