Abstract
The objective of the study: to assess efficiency of comprehensive treatment of destructive pulmonary tuberculosis patients with extensive drug resistance using valve bronchial block. Subjects and Methods. Treatment outcomes in 60 patients with destructive pulmonary tuberculosis and extensive drug resistance were analyzed, the age of patients varied from 18 to 60 years old. The main group included 30 patients who had valve bronchial block along with treatment by third line drugs, the comparison group included 30 patients who had the same treatment but with no valve bronchial block. Pneumoperitoneum was used in both groups, should there be indications for it. The significance of difference was defined by χ2 test, the difference was considered significant with p 0.05), and the one confirmed by culture – in 5 (16.8%) patients versus 18 (60.0%) respectively (p > 0.01).
Highlights
EFFICIENCY OF VALVE BRONCHIAL BLOCK WITHIN COMPREHENSIVE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE
The bacillary excretion persisted in fewer cases: the one confirmed by smear was persistent in 3 (10.0%) patients from the main group versus 9 (30%) from the comparison group (p > 0.05), and the one confirmed by culture – in 5 (16.8%) patients versus 18 (60.0%) respectively (p > 0.01) Key words: tuberculosis, extensive drug resistance of M. tuberculosis, valve bronchial block
В основную группу (ОГ) включено 30 пациентов, у которых в комплексной терапии с использованием препаратов 3-го ряда был применен метод клапанной бронхоблокации, группу сравнения (ГС) составили 30 пациентов, получавших аналогичное лечение без применения клапанной бронхоблокации
Summary
Treatment outcomes in 60 patients with destructive pulmonary tuberculosis and extensive drug resistance were analyzed, the age of patients varied from 18 to 60 years old. The bacillary excretion persisted in fewer cases: the one confirmed by smear was persistent in 3 (10.0%) patients from the main group versus 9 (30%) from the comparison group (p > 0.05), and the one confirmed by culture – in 5 (16.8%) patients versus 18 (60.0%) respectively (p > 0.01) Key words: tuberculosis, extensive drug resistance of M. tuberculosis, valve bronchial block. При этом имеется высокий уровень туберкулеза с множественной (МЛУ-ТБ), в том числе с широкой лекарственной устойчивостью (ШЛУ-ТБ). На диспансерном учете по РК состояли 10 575 больных МЛУ-ТБ, в том числе ШЛУ-ТБ [4, 6]. В настоящее время уже имеется много сообщений об эффективности клапанной бронхоблокации, одними из первых были публикации, посвященные лечению полостей распада при инфильтративном туберкулезе, в том числе и с лекарственной устойчивостью [3, 5]. Цель исследования: оценить эффективность комплексной терапии больных деструктивным туберкулезом легких с ШЛУ МБТ при применении клапанной бронхоблокации
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