Abstract
Normal and two-kidney one-clip hypertensive (RVH) Wistar rats were fed ethanol in their drinking water in concentration of 10% for eleven weeks.Blood pressure were monitored and levels of serum lipids (TC, EC, TG, TPL, HDL-C) were determined.After sacrifice, the entire heart was weighed. Hydroxyproline content in aorta and left ventricle, and elastin content in aorta were measured.There were no further augumentation in blood pressure both in normal and RVH rats fed with ethanol.Serum TC, TPL and HDL-C decreased in RVH rats, while ethanol-fed RVH animals showed no changes.Heart weight to body weight ratios were maximal in ethanol-fed RVH rats (p<0.01vs. RVH rats).Hydroxyproline content in left ventricle was maximal in ethanol-fed normal rats (p<0.01vs. RVH and RVH-ethanol groups). Elastin content in aorta decreased in RVH-ethanol group (p<0.01vs. ethanol-fed group).These data indicate that ethanol administration has quite different influences on RVH-rats from that on normotensive rats.
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