Abstract
Effects of nooclerin (deanol aceglumate) and slavinorm (vascular polypeptide complex) on the breathing and heart rates were compared in Wistar rats in the course of progressive hypothermia. The animals were immersed in water at 9 ± 0.4 °С. The parameters under study were breathing rate (BR), heart rate (HR), rectal temperature (Тr), esophageal temperature (Tes), and arterial saturation (SpO2). In comparison to controls, at the beginning of hypothermia BR in experimental rats was high at lower Tr values. Nooclerin did not change the trend of HR curve dependence on Tr, whereas slavinorm shifted the trend toward high HR values; besides, it more than doubled life duration before the respiratory arrest. This occurred as a result of rats' transition in the state of cold-hypometabolism when the cardiac activity was maintained by slow breathing. The investigation showed that nooclerin and slavinorm are able to preserve the viability of organisms in hypothermic environment. Both drugs enhance and extend the stage of breathing activation at the beginning of cold immersion in the experimental rats in comparison to their controls. Injection of nooclerin and slavinorm mobilizes the defenses of organism and reduces the pathological effects of deep hypothermia.
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