ОЦЕНКА КЛИНИКО-БИОХИМИЧЕСКОГО АНАЛИЗА КРОВИ СОБАК С УЧЕТОМ ПРИМЕНЕНИЯ ОСТЕОБИОКОМПОЗИТА ДЛЯ УСКОРЕНИЯ КОНСОЛИДАЦИИ

Abstract

To date, it is quite important to prevent antibacterial contamination, osteoconductivity and osteoinductivity of the processes of reparative regeneration of bone tissue with the help of coatings for implants, as well as a variety of pharmacological drugs administered systemically or pointwise into the fracture zone. This is necessary to prevent degenerative-dystrophic changes in the osteoarticular system (false joint, arthrosis, resorption, sequestration, slow consolidation, non-fusion, osteoporosis, reduced vascularization), acute and chronic infectious lesions, joint blockage, deformity of tubular bones and disability. This article reflects the studies of clinical and biochemical blood analysis of three groups of animals (dogs) using the developed biocomposite injected into the intramedullary canal with a simulated transverse fracture of the middle third of the radius diaphysis. The components of the composite are used as: a matrix that compensates for parts of the destroyed bone, accelerates the processes of renewal of structural parts of cells, tissues at various stages of organization, while it has a stimulating effect on leuko- and erythropoiesis, as well as the process of phagocytosis, bone formation, prompting osteoprogenitor cells to proliferate and differentiate into osteoblasts. Also, due to the presence of a semi-synthetic broad-spectrum antibiotic (penicillin series), it has a bactericidal effect as a result of inhibition of bacterial cell wall synthesis. It is also worth noting that the developed composite is safely absorbed and biointegrated without reaction to a foreign body. Based on the conducted studies, a group of authors, taking into account the clinical and biochemical analysis, confirmed the absence of inflammatory, allergic, aplastic, hepatotoxic and nephrotoxic reactions from the macro- and micro-organism of animals.