Abstract
Abstract. Depression is a destructive syndrome, with allostatic overload and transient dysregulation of neurological, metabolic and immunological status functions, as well as reprogramming in the hypothalamic-pituitary-adrenal axis. Depression causes pathological changes in the secretion and motility of the digestive system, and failure of bidirectional intestinal-brain connections modify the intestinal microbiota. Chronic depression destabilizes the “cognitive and visceral brain”. The neuroendocrine component of the new neural network brain models and controls molecular, functional, behavioral and Autonomous responses in response to the formation (creation, cultivation) of a new healthy biomicrobiota. Constant self-organization of functional systems of the body is provided by homeostatic regulation in the framework of deterministic and stochastic science. The architecture and functions of the brain support efficient energy regulation. The internal model of the brain negatively affects the development and maintenance of depression. For example, mood, motor, autonomic, immune, metabolic, and circadian dysregulations indicate a Central problem with ineffective energy regulation. Depression is an internal pattern associated with distress, mental withdrawal from the world, and physical withdrawal from the world. Allostasis and depression, allostatic dysregulation and instantaneous distress are based on the fundamental multidisciplinary role of metabolism. The author's work in the creation of a new protective functional and epigenetic nutrition, the clinical application of strategic combined and hybrid methods and tools in the neurorehabilitation of the circadian system, the use of artificial intelligence in the functioning of the “cognitive brain” and “visceral brain” and the “brain-microbiota” neural networks are promising applications in personalized medicine. Psychoneuroimmunological communications and neuroendocrinological multimodal methods can significantly increase the duration of an active and high-quality healthy life.
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