Abstract
The occurrence of dental caries is mainly associated with oral pathogens, especially cariogenic Streptococcus mutans and Porphyromonas gingivalis. The objective of this study was to investigate antimicrobial activity against cariogenic associated pathogens, acid tolerance, bile salt tolerance, and autoaggregation of 12 presumptive Lactobacillus spp. isolated from human and fermented foods. Five strains were selected after qualitatively identifying high levels of antimicrobial activity against bacteria including S. mutans. Results show that selected strains survivability was tested in bile salt and acidic conditions to show their potential use as probiotics in the gastrointestinal tract. Indirect adhesion activity of selected strains measured by autoaggregation assay showed more than 60% autoaggregation after 5 h standing. Further studies are underway to demonstrate that the selected strains can be applied as potential probiotics for recovering oral ecosystem.
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