Abstract
Principles of tissue engineering include scaffold materials, stem cells and regulatory factors. With the availability of blood supply, an organ can be regenerated. Scaffold materials such as collagen, hydroxyapatite and polylactic acid, stem cells such as mesenchymal stem cells (MSC), adipose tissue derived stem cells (ASC) and induced pluripotent stem (iPS) cells, and regulatory factors such as basic FGF, IGF-1 and HGF have been utilized. Langer and Vacanti proposed “tissue engineering,” wherein they proposed creating tissues outside the body and then implanting them into the body; however, their implanted tissues became absorbed in the body in animal experiments. In contrast, our concept of “in situ tissue engineering” is designed to mediate the healing and tissue re-growth within the body itself.
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