ОЦЕНКА СОСТОЯНИЯ ИММУННОГО ОТВЕТА У БЕРЕМЕННЫХ С ПЛАЦЕНТАРНОЙ НЕДОСТАТОЧНОСТЬЮ С УЧЕТОМ ТЯЖЕСТИ ЦЕРЕБРАЛЬНОЙ ПАТОЛОГИИ У ИХ НОВОРОЖДЕННЫХ

Abstract

Purpose. The study of immunological mechanisms of hypoxic-ischemic brain damage of varying severity in infants born to mothers with placental insufficiency. Materials and methods. A clinical and laboratory examination of 58 pregnant women with placental insufficiency in the period 38-39 weeks of pregnancy. The subjects were divided into subgroups: 1a - perinatal CNS lesions with an average degree of severity, clinically detectable at birth (n = 31), 1b - perinatal CNS damage with mild severity, clinically detectable at 1 month after birth (n = 27). The control group consisted of patients with physiological pregnancy and childbirth (n = 19). Results. It was revealed that the criterion of hypoxic-ischemic central nervous system in newborns is to increase the mother’s blood level of CD16 + NK-cell activation markers of T-cell CD69 +, CD25 +, apoptosis markers CD95 +, AnnexinV +, AnnexinV + PI +, shift the cytokine balance in favor of pro-inflammatory cytokines ( TNF-α, IL -6, IFN-γ), both in serum and amniotic fluid. Conclusions. The development of hypoxic-ischemic brain damage in newborn infants of mothers with placental insufficiency occurs against violations of the mechanisms of immune response.