Abstract
Current review is aimed at experimental approaches being currently used to study basic mechanisms of alcohol abuse. Here we analyze in details the main strategies for developing animal models: forced alcohol exposure, free-choice alcohol intake, intermittent access to alcohol, operant self-administration, compulsive-like aversion-resistant intake. The impact of various types of alcohol exposure (alcohol-containing diet, exposure to ethanol vapor using inhalation, per os alcohol administration, etc.), genotype and age of the animals in producing alcohol dependence are discussed. In sum, this review highlights advantages and limitations of different methodologies for translational research on alcohol use disorder.
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