Abstract
The parameters of moisture content, hygroscopicity, and thermal desorption of stearic acid, calcium stearate, and magnesium stearate, which are used as auxiliary components in the tablet manufacturing technology, have been investigated. It is established that calcium stearate and magnesium stearate, in contrast to stearic acid, are hygroscopic compounds that are capable of absorbing moisture from air under the conditions of increased relative humidity. The absorbed water occurs in the samples in both bound and free states and is vaporized in the temperature range of 40 - 105°C. The endothermic effects for calcium stearate (Tmax = 125.7°C) and magnesium stearate (Tmax = 113°C) are related to the melting of the crystalline phases of these compounds and their transformation into an amorphous state. The studied samples of auxiliary substances had different initial water contents and absorption capacities, depending on the origin (supplier company), which makes the preliminary investigation of these parameters of great importance.
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