Abstract
Theophylline pharmacokintics at night were evaluated in 20 mild to moderate asthmatic inpatients aged 63.9±13.2 yr (mean±SD) who had been administered a once-a-day theophylline preparation “Uniphyl Tablet” while the serum theophylline concentration was predicted using a pharmacokinetic analysis program designed exclusively for this preparation. The patients were administered the drug daily at 18: 00 pm after dinner. Fourteen patients received a multiple dose (steady state) while six received a single dose. Blood samples to determine the serum theophylline concentration were drawn at 0 (immediately before drug administraton), and at 3, 6, 9, 12 and 15 hours after administration. Tmax was 9.6±2.4 at a steady state and 9.0±2.47 hr at a single dose state, respectively. These findings thus suggest the most suitable time of administration of this preparation to be at from 18: 00 to 20: 00 pm after dinner. In addition, little differnce was observed between the predictive value and observed one. The confidence of the predictive value at 3: 00 and 6: 00 am was high, however, the predictive value also tended to be over predictive in patients whose theophylline clearance was large.
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