Abstract
Effects of additives on the asymmetric yield of methyl 3-hydroxybutyrate were examined in the hydrogenation of methyl acetoacetate using Ni-Pd-Kieselguhr catalyst modified with tartaric acid. Addition of unsaturated compounds such as dehydroacetic acid and diethyl maleate showed almost no effect on the asymmetric yield. Only when carboxylic acids having pKa values higher than that of tartaric acid such as formic acid, acetic acid, benzoic acid, and succinic acid were used as additives, great increase in asymmetric yield was observed.
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