Abstract
Co-cultivation with Vero or B95a cell lines was used to study the biological and serological properties of 15 strains of canine distemper virus (CDV) isolated from dogs in Japan from 1982 to 1998. Those properties were then compared with those of the CDV vaccine strain used in Japan. The vaccine strain and some of the fieldisolates cultured in Vero cells demonstrated proliferation potency in chicken embryonic fibroblast cell culture and pock-forming capacity and neurovirulence in suckling mice. Cross-neutralization tests using 9 fieldisolates, and the vaccine strain revealed no significant antigenic difference among the field-isolates. The fieldisolates were, however, somewhat different strain from the vaccine strain in antigenicity. Since the antiserum to the vaccine dramatically neutralizes all the field-isolates, the vaccine used currently in Japan can be considered effective against recently isolated CDV strains.
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