Abstract
To clarify the role of platelets on cancer metastasis formation, we have studied the inhibitory effect of various antiplatelet agents on hematogenous metastases. We have revealed that platelets played an important role on the growth of metastatic foci as well as the lodgement of tumor cells.Combined inhibitory effect of antiplatelet agents and cyclophosphamide on metastases was obtained in mice treated with each agents, particulary diltiazem. NK activity of spleen cells was inhibited in mice treated with any antiplatelet agents.Relationship between inhibition of NK cell activity and enhancement of i. v. induced pulmonary metastases by trypsin-treated 3 LL cells was observed in mice treated with antiplatelet agents. PDGF showed the potent enhancing effect on tumor growth in each metastatic step.In conclusion, antiplatelet therapy was effective on the inhibition of tumor growth in pulmonary metastatic foci, and its inhibition was increased by the combination with anticancer agents. Disadvantage of inactivation of host cells such as NK cells by antiplatelet therapy should by considered against circulating tumor cells. Inhibition of release of PDGF by antiplatelet therapy suggested the marked usefulness on the inhibition or prevention of tumor growth and metastasis formation.
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