Abstract
Dispersion performance of Dry Powder Inhaler (DPI) depends largely upon the inhalation patterns of patients. In the present work, the inhalation patterns of healthy and COPD subjects with DPI were measured and a breathing simulator was constructed. Then, a measurement method with a gravitational settling chamber that allowed the particle size measurement without the dispersion during the measurement was proposed for the measurement of DPI dispersion performance under the simulated inhalation conditions. As a result, it was found that an increase in pressure drop of DPI markedly reduces the peak flow rate and that the dispersion performance of DPI is greatly affected by the inspiration patterns. The experimental data also suggested that Andersen impactor which is commonly used for the evaluation of dispersion performance of DPI is not suitable for this purpose because the dispersion of drug particles in the impactor is inevitable.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Society of Powder Technology, Japan
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
