ПЕРВЫЕ РАДИОПРОТЕКТОРЫ: ДЛЯ ОПЫТОВ IN VIVO ОФИЦИАЛЬНАЯ ИСТОРИЧЕСКАЯ ВЕХА ОТОДВИГАЕТСЯ НА ШЕСТЬ ЛЕТ

Abstract

Historical essays in monographs, in reviews and in the introductions of experimental works on theme of the first studies of radioprotectors are considered. It was found that such studies began to be carried out only during the development and use of atomic weapons, but not during the previous order of 40 years of radiotherapy (with the exception of the effect of hypoxia as such, and not caused by drugs). In most publications, the work of Patt H.M. et al., 1949 on the cysteine action (USA) is called as pioneer research, what is not quite right (it is only right for thiol compounds). A paper by Joseph Maisin (Belgium) in the journal ‘Acta Biologica Belgica’ which published only in 1941–1943 in the occupied Brussels, should be considered as a real milestone for animal experiments (Vol. III–IV. P. 117). In this study, referenced only in a single work (Bacq Z.M. et al., 1951), the radioprotective effect of p-aminobenzoic acid (PABA) was demonstrated in rodents. In the same year, the radioprotective effect of estrogens was shown in mice (Treadwelal A. DEG. et al., February 1943). A brief summary of the stages of radioprotective agents study is presented, starting from 1942 (W.M. Dale et al.; protection of the enzyme in solution) and up to the 1954, when all the main classes of radioprotectors were discovered and the corresponding mechanisms of effects were proposed.