Abstract
We summarised and analysed here the findings on apoptosis contribution into the cell damages, caused by temperature deviation from the physiological norm (below 37°C). The participation of the caspases, causing the disintegration of anti-apoptotic Bcl- 2 family proteins and proteolysis of the DNAase inhibitor, responsible for DNA fragmentation in the apoptosis, induced by a moderate cell cooling, was shown. An important role in cold adaptation mechanism belongs to the RNA-binding protein (cold-inducible RNAbinding protein, CIRP), which is capable to prevent the oxidative stress-induced apoptosis development. We reported here the data, confirming the participation of reactive oxygen species and antioxidant cell components: superoxide dismutase and human peroxiredoxin 1 in apoptosis and cold adaptation. Probl Cryobiol Cryomed 2017; 27(2): 97–109
Highlights
We summarised and analysed here the findings on apoptosis contribution into the cell damages, caused by temperature deviation from the physiological norm
In multicellular organisms the apoptosis is involved into differentiation and morphogenesis, maintenance of cell homeostasis and providing the essential components of immunoreactivity
The findings showed the cold-inducible RNAbinding protein (CIRP) content under hypothermia in the standard culture cells and in those with CIRP overexpression to be significantly higher, and the apoptosis level to be significantly lower as compared to the control cells, cultured at 37°C
Summary
Активация митохондриальных механизмов апоптоза клеток (рис. 1). Многочисленные данные указывают на то, что для большинства клеток апоптоз является типичной реакцией на гипотермию и последующий отогрев [20, 24].
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