Abstract
Scorpion toxins that block potassium channels currently serve as indispensable molecular research tools in neuroscience. However, there is a grave shortage of compounds that selectively act on particular channel isoforms. Earlier, from the venom of the Central Asian scorpion Mesobuthus eupeus, we have isolated a number of toxins that act on voltage-gated potassium channels. Now, we have studied the activity of two similar M. eupeus toxins, named MeKTx13-2 and MeKTx13-3, on a panel of potassium channels and found that they are characterized by a selective effect on the Kv1.1 isoform, the expression of which is characteristic of the central nervous system of mammals. We believe that our results will allow to obtain derivatives of toxins with increased selectivity for Kv1.1, which will be in demand in studies of the nervous system.
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