Abstract

본 연구는 정상적인 안압을 가진 비글견에서 4가지의 다른 농도를 가진 lidocaine을 사용하여 앞쪽목신경절차단 후 안압의 변화를 관찰하기 위하여 시행하였다. 실험군은 전향적 교차시험으로 10두의 비글견을 2%, 1%, 0.5% 및 0.25% lidocaine group으로 4군으로 나뉘었다. 모든 실험견들은 4 가지의 다른 농도를 가진 2 ml의 lidocaine을 사용하여 각 4번의 앞쪽목신경절 차단을 받았으며 신경 차단은 무작위로 1주일 간격으로 각각 시행되었다. 실험결과 호르너 증후군은 모든 실험군에서 관찰되었다. 1% lidocaine group에서는 대조군과 비교하여 차단 후 5분에서 안압의 유의한 상승이 있었으며(p<0.05), 2%와 1% lidocaine group의 안압은 앞쪽목신경절 차단 후 25분과 45분 사이 감소하였으나, 0.5%와 0.25% lidocaine group은 변화가 없었다. 이상의 결과를 종합하면, 앞쪽 목신경절 차단술은 정상 안압의 변화에 영향을 미치며 0.5%와 0.25% lidocaine은 안압을 변화시키기에는 부적당한 농도로 사료된다. This study was performed to observe changes of the intraocular pressure following cranial cervical ganglion block with the four different concentrations of lidocaine in beagle dogs with the normal intraocular pressure. We performed by the crossover test in ten beagle dogs divided into four groups, which were 2%, 1%, 0.5% and 0.25% lidocaine group. All experimental dogs received each four times cranial cervical ganglion block using 2 ml of lidocaine with the four different concentrations. The blocks were separately done at a week intervals in random order. Horner#s syndrome was observed in all groups. The intraocular pressure in the blocked side was significantly increased to 5 min in the 1% lidocaine group compared to the baseline (p<0.05). The intraocular pressure of 2% and 1% lidocaine groups were decreased between 25 and 45 min following cranial cervical ganglion block, while those of 0.5% and 0.25% lidocaine groups were unchanged. In conclusion, these results suggest that cranial cervical ganglion block affect on the change of intraocular pressure and 0.5% and 0.25% lidocaine are inadequate concentrations for the change of intraocular pressure in the dog with normal intraocular pressure.

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