Abstract
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing Chronic Kidney Disease in the long-term. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option.
Highlights
In 2014, over 600 million adults worldwide, 18 years and older, were obese
Obesity is a potent risk factor for the development of kidney disease. It increases the risk of developing major risk factors for chronic kidney disease (CKD), like diabetes and hypertension, and it has a direct impact on the development of CKD and end-stage renal disease (ESRD)
Central fat ± obesity associated with diminished filtration
Summary
In 2014, over 600 million adults worldwide, 18 years and older, were obese. Obesity is a potent risk factor for the development of kidney disease. This article reviews the association of obesity with kidney disease on the occasion of the 2017 World Kidney Day. Over the last 3 decades, the prevalence of overweight and obese adults (body mass index [BMI] ≥25 kg/m2) worldwide has increased substantially.[1] In the United States, the ageadjusted prevalence of obesity in 2013 to 2014 was 35% among men and 40.4% among women.[2] The problem of obesity affects children. In a population-based study of 5.24 million individuals from the United Kingdom, a 5 kg/m2 higher BMI was associated with a 25% higher risk of kidney cancers, with 10% of all kidney cancers attributable to excess weight.[28] Another large analysis examining. 2354 community-dwelling individuals with normal kidney function aged 28-40 years
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