Abstract
The incidence of myocardial infarction (MI) among women of working age has continued to grow in recent years, being a great socio-economic problem. The purpose — to study the features of MI course in women under the age of 60. Results. The following risk factors were identified: hyperlipidemia (74.2%), arterial hypertension (AH) (69.4%), smoking (35.5%), obesity (37.1%), and diabetes mellitus (DM) (29.0%). Hyperuricemia (HU) occurred in 38.7% of patients. Repeated MI was observed in 3.2% of patients. Anterior and lower MI occurred with approximately the same frequency (45.2% and 40.3%, respectively). The percentage of coronary artery (CA) lumen stenosis was 81.2 ± 19.6%. Thrombosis with complete CA occlusion was detected in 61.3%. The percentage of brachiocephalic artery (BCA) lumen stenosis was 21.5 ± 7.5%. Thickness of the intima-media complex (TIMC) of BCA in the carotid artery bifurcation zone was 1.1 ± 0.2 mm on the right and 1.1 ± 0.2 mm on the left. We revealed a direct correlation between the level of uric acid (AU) and TIMC BCA (correlation coefficient 0.36; p ˂ 0.05) and an inverse correlation between the UA values and the glomerular filtration rate (GFR) (correlation coefficient 0.36; p ˂ 0.05), which indicates the important role of HU. Conclusions. Among the risk factors of MI development in women under 60 years of age, hyperlipidemia, hypertension, smoking, HU and DM are of the greatest importance. Hemodynamically significant stenosis was only in CA, multifocal atherosclerosis was not detected. HU is the most important factor of MI development in women. It has a negative effect on BCA and GFR and increases the likelihood of a brain stroke. It is necessary to include UA in the standards of examination of all forms of coronary heart disease. In case of a high cardiovascular risk, it should be reduced to the target level below 360 mmol/l to prevent cardiovascular complications.
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