Abstract
Thyroid hormones, antibodies to thyroglobulin, and cytokines tumor necrosis factor a (TNF-a) and interleukin 1 (IL-1) were measured in 14 patients with diffuse toxic goiter (DTG) and 6 patients with Hashimoto ’s autoimmune thyroiditis (AIT). Patients with DTG were examined in the presence of hyperthy- rosis and those with AIT in the presence of euthyrosis. The data indicate a relationship between the levels of TNF-a and thyroid hormones: negative correlation in hyperthyrosis and positive in euthyrosis. In addition, patients with AIT develop a direct correlation between TNF-a and serum titer of antithyroglobulin antibodies. Serum level of IL-1 do not increase. The results of this study confirm the hypothesis about important role of cytokines in pathogenesis of autoimmune diseases of the thyroid, namely, DTG and AIT.
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