Abstract
One of the important areas of research into the pathogenesis of diseases caused by pathogens of especially dangerous infections is the study of the system of hydrolytic enzymes. It has been established that hydrolytic enzymes of pathogenic microorganisms enhance their pathogenicity (virulence) and participate in the processes of adaptation to unfavourable environmental factors. Cholera vibrio has previously electrophoretically detected hydrolases belonging to different subclasses and established differences in their spectrum in strains with different epidemic significance. Therefore, the study of their characterisation (type determination using activator/inhibitor assays) is a relevant area of research. The inhibitor analysis of secreted proteases of cholera vibrio strains of O1 serogroup El Tor biovar and O139 serogroup determined that the proteases include serine and metalloproteases.
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