РІВЕНЬ ПРОЗАПАЛЬНИХ ЦИТОКІНІВ ЗА УМОВ ЛУЖНОГО ОПІКУ СТРАВОХОДУ 2-ГО СТУПЕНЯ ТА ПРИ ВВЕДЕННІ ЕКСТРАКТУ СТРУЧКІВ PHASEOLUS VULGARIS

Abstract

The frequency of damage due to poisoning with chemicals is increasing. Chemical burns are the most common pathology of the esophagus in children. As a result of penetration of alkalis and contact with the wall of the esophagus, along with necrosis, damage to the mucous membrane, submucosal and muscular membrane of the esophagus occurs. Despite a large number of drugs that have been tested in the treatment of complications caused by esophageal burns, there is little information that would indicate the high effectiveness of the previously used drugs. When treating chemical burns of the esophagus there are many complications. Full restoration of the functional status of immunity is an important step in the complex therapy of treatment of chemical burns of the esophagus. The analysis of literature data shows the positive influence of polyphenols of natural origin on the normalization of physiological and biochemical parameters in various pathologies. The extract of common beans (Phaseolus vulgaris pods extract (PVPE)) is an example of a rich bioactive component of the source with beneficial characteristics for humans. Therefore, the purpose of our work was to investigate the level of proinflammatory cytokines (IL-1β and IL-6) in blood serum of rats in the simulation of alkaline esophageal burns of 2 degrees at 7th,15th, 21st and 31st days and for the introduction of Phaseolus Vulgaris pod extract. During our study, it was found that during alkali burns esophagus second degree, marked and prolonged increase in marker proinflammatory cytokines IL-1β and IL-6, which could cause the formation of granulated tissue, resulting in the formation of scars, violation of reparative regeneration and delayed healing of burn wounds. The content of proinflammatory cytokines in a group of animals with treatment is lower compared with the group with burns without treatment during the experiment time, which may indicate the expressed therapeutic effect of the extract of beans pods in alkaline burns of the esophagus.