Оптимизация протокола макроскопического исследования почки после нефрэктомии при новообразовании

Abstract

Introduction. Nephrectomy is most often performed to treat kidney cancer. Literature suggests that malignant neoplasms can develop paraneoplastic glomerulopathies and metabolic disorders, including nephropathies. Moreover, glomerulopathies and metabolic disorders may not be associated with a tumor. The aim of the study was to develop a method for gross examination of the kidney with a tumor obtained after nephrectomy, with attention being paid to sample collection for immunofluorescence and electron microscopy. Materials and methods. I analyzed 171 kidney samples after nephrectomy due to tumors to detect the appropriate distance for kidney parenchyma sampling from the tumor on a pilot basis. Results. I present an optimized protocol for kidney gross examination after nephrectomy due to a neoplasm. I estimated the appropriate distance from the tumor for sampling the kidney parenchyma to be at 3 cm. Conclusion. Glomerulopathies are characterized by bilateral lesions, regardless of their origin. Often being asymptomatic or oligosymptomatic, they lead to a decreased kidney function. The simultaneous morphological diagnosis of glomerular pathology in patients with a kidney tumor may be the only option to diagnose glomerulopathies in time. The described method allows a reliable diagnosis of glomerulopathy in these patients. This, in turn, will help health care providers to initiate therapy in good time and prevent rapid disease progression.